1.READ THIS FIRST (03/13/2013 update)

Important Information about

Low Dose Naltrexone

Low Dose Naltrexone is neither an overall immune “suppressant”, nor an immune “booster”. LDN orchestrates the immune system and works to restore homeostasis (balance) in whatever way you need. This is the reason it works well for so very many different conditions, diseases and symptoms.

Low Dose Naltrexone is an exception to the saying ‘if something sounds too good to be true, it probably is’.

PLEASE READ THIS ENTIRE DOCUMENT *BEFORE* STARTING LDN. Avoid the mistakes many people make with the starting amount and timing of the dosage…

Feel free to forward this to anyone you know who has a chronic condition

How Does LDN Work?

The video at http://www.ldnscience.org/ explains the action of LDN. Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, differentiating it from opioids that are administered from external sources. Endorphins are produced in most cells in the body, and are important regulators of cell growth and, therefore, the immune system. Disorders of the immune system can occur with unusually low levels of endorphins. The particular endorphin that has been found to influence cell growth and immunity is called Opioid Growth Factor (OGF) or Metenkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor. For the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptor, it displaces the body’s naturally-produced OGF. As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to capture more OGF.
  3. Production of OGF is increased in order to compensate for the perceived shortage of OGF.

Since LDN blocks OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect interact with the more-sensitive and more-plentiful receptors – all to assist in regulating cell growth and immunity.

The duration of the rebound effect varies from individual to individual, but generally persists for about one day. The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone, or using a timed-release formulation, will result in continuous blockade of OGF receptors, and there will be no rebound effect.

The use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’, whilst the use of low-dose Naltrexone results in ‘temporary opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid full-dose and timed-release versions of the drug.

Individuals vary in their metabolic speed and this will result in variation of the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3 mg and 5 mg is suitable for most patients, modification of the dosage is sometimes needed.

The beneficial effects of Low Dose Naltrexone were first discovered by Dr. Bernard Bihari, M.D., a physician in New York City treating addicts, some of whom also had Multiple Sclerosis. He discovered that a small dose stimulates the body to greatly increase production of endorphins, enkephalin and metenkephalin, which orchestrate the immune system. Although Dr. Bihari did much of the early clinical work, Dr. M. Zagon did groundwork with animal research studies at Pennsylvania State University. Multiple Studies have been done that prove the efficacy of LDN for multiple conditions.

In 2007 The American Journal of Gastroenterology published Dr. Jill Smith’s Penn State LDN Trial with a small group of Crohn’s sufferers. 67% went into remission and 89% showed improvement: http://www.ncbi.nlm.nih.gov/pubmed/17222320. Her second larger Trial yielded more great results: http://api.ning.com/files/8gos8*N7Z7vvpKWIW*mQnFAbzT7tktUr-Rz0p40C-SrjURj0O4WkkOW2TqwCyx3gj4v-BdMqQHUEVohnIgYoW8B0LF4P7yJS/Crohns2011.pdf.

MS Trials:  http://www.ncbi.nlm.nih.gov/pubmed/18728058?ordinalpos=&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.SmartSearch&linkpos=1&log$=citationsensor

http://onlinelibrary.wiley.com/doi/10.1002/ana.22006/abstract

Glioma Trial now recruiting participants — Katherine B Peters, MD, PhD, a neuro-oncologist at Duke University, is the principal investigator. The placebo-controlled, randomized clinical trial will involve 72 patients, all of whom have high-grade malignant Glioma. They will receive, in addition to standard chemo-radiation, either placebo or LDN. For further information, please contact: Sarah Woodring at 919-684-2527. Further details about the trial can be found here:  http://clinicaltrials.gov/ct2/show/NCT01303835

Cancer Studies: http://www.ncbi.nlm.nih.gov/pubmed/16484716?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6

Fibromyalgia Studies: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891387

http://curetogether.com/blog/2011/10/05/stanford-fibromyalgia-study-on-ldn-replicated-at-curetogether

Many people with ONE immune/autoimmune condition will go on to get more. This is called a “constellation”. For example, people often have EBV, Hashimoto’s & Interstitial Cystitis together. A constellation may appear over a period of years. So … should you have only one condition, this is an extremely good and urgent reason to begin LDN as soon as possible to prevent the piling on of other conditions now that your immune system is damaged.

Many healthy people take LDN for anti-aging, and to increase stamina such as Dr. Berkson, the ALA guru:  http://www.honestmedicine.com/2009/03/burt-berkson-md-phd-talks-with-honest-medicine-about-his-work-and-our-medical-system-the-interview-t.html

Read Francie’s post:  http://ldn.proboards.com/index.cgi?board=personal&action=display&thread=2496

“I am not saying that LDN is a cure-all. For the most part, it is only a treatment, not a cure… In some cases, it works wonders… To the best of my knowledge, however, there has never been a drug that could help so many different conditions at such a low cost and with so few side effects. To me, that is a wonder!”  –Dudley Delany, LDN user/advocate.

FAQS with a Physician & an LDN Expert

Q: I am on long-term Opiate pain medication. Can I take LDN now?
A: NO. Long-term opiates, taken regularly several times per day, cannot be used for at least 2-3 WEEKS, if not longer, prior to starting LDN. If you are on long-term opiates, work with a medical professional as you make the change to LDN. To simplify, LDN will rip the opiates from the endorphin receptors in your body, causing withdrawal symptoms. If the use of opiates is intermittent or ‘as needed’ and not taken daily/several times per day, LDN can be started cautiously at a lowered dose (.50 mg) as a test. If there is a withdrawal reaction that is unbearable, stop LDN and wean off the opiates for a week or two; then try again. Once on LDN for good, a single dose of an opiate 12 hours after the dose of LDN can be attempted only as needed; however, Tramadol is the only recommended opiate for this type of temporary use. Again, if there is a reaction, change to a non-opiate pain medication.

Low-Dose Naltrexone can be made by the individual, or compounded at various pharmacies. LDN is not a radical treatment. Tell your physician that you wish to try a well-known FDA approved drug at 10 times a smaller dose than usually taken, and that you can do it under his supervision, which you would very much appreciate, or you can do it on your own.  Often doctors will respond to this way of looking at the topic in a positive way. Try rating your pain and symptoms on a scale of 1 to 10 and sharing your (hopefully vast) improvement with the doctor as you titrate LDN from .50 or 1.0 mg, to whatever dosage you eventually settle upon.

Many LDN users report no need for prescription pain medication of any kind as long as they are on LDN. LDN will make all opiates work better, due to the great increase of endorphin receptors, so use caution and take a lower dose. PLEASE READ “Drugs that may interact with LDN” and “Drugs not to take with LDN”, found in this packet.

Q: I heard that LDN works because of the placebo effect. Is this true?
A: NO. Some naysayers claim that the reason LDN works for millions of human beings is because of the placebo effect. Research with animals shows marked and measurable improvements in their diseases. Animals do not read and cannot grasp what a placebo is, so their improvement cannot be attributed to the placebo effect. LDN does nothing except shut down your body’s endorphin production and cell receptors for a short period, and this brief switch-off basically tricks production of endorphin, enkephalin and metenkephalin into high gear.

Q: I heard someone say they take LDN, but they are not sick.
A: Many healthy medical practitioners take LDN and prescribe it to the entire family–children and pregnant/nursing women included–as a preventative for cold, flu and virus, and to prevent infection with many chronic and autoimmune diseases. It is the experience of many LDN users that as long as they are on it they rarely experience colds, flu, viruses, depression or anxiety and if they do get a cold/flu, they are able to fight the infection off more quickly than usual and get far fewer secondary infections.

Q: Can I take LDN if I am trying to get pregnant?
A: LDN is said to be safe during pregnancy. Dr. Phil Boyle, a specialist in fertility says:  “I am confident that LDN is perfectly safe in pregnancy and in certain cases will actually reduce the risk of miscarriage. I have been prescribing LDN regularly during pregnancy… and the results have been excellent. Clinical experience has proven to me that it is safe. We’ve had over 50 babies whose moms have been on LDN throughout their pregnancies and those babies, if anything, have been even healthier than those whose moms haven’t been on [low dose] Naltrexone.”

A Letter to give to your medical professional (slightly edited)

“LDN is a major breakthrough, but like other innovative therapies, it’s virtually ignored by conventional physicians. It’s the same old song and dance:  ‘If it were any good, I’d know about it.’  Yet this safe, economical drug stands to benefit millions – not only those with cancer and MS, but also people dealing with autism, Parkinson’s, fibromyalgia, chronic fatigue syndrome, and other autoimmune diseases.

Cancer in Remission  A promising area of treatment is cancer. Burton Berkson, MD, and colleagues published a paper describing four case histories of patients with metastatic pancreatic cancer who were treated with LDN plus intravenous alpha lipoic acid (a potent antioxidant). Before we go on, you need to understand that the prospects for patients with pancreatic cancer are terrible. Most of them live only a few months after diagnosis, and the five-year survival rate is a dismal four percent. It’s essentially a get your affairs in order prognosis. Two of the patients Dr. Berkson reported on, each with well-documented pancreatic cancer that had metastasized to the liver, were alive and well 78 and 39 months after presenting for treatment. A third patient who had the same diagnosis was disease-free, as evidenced by a PET scan, five months after beginning LDN/alpha lipoic acid therapy. The final patient had a history of B-cell lymphoma and prostate adenocarcinoma in addition to metastatic pancreatic cancer. After four months of treatment, his PET scan demonstrated no signs of cancer. [There have been] good results in patients with melanoma, non-Hodgkin’s lymphoma, cancer of the breast, lung, prostate, kidney, and colon… this safe, inexpensive drug is certainly a reasonable adjunctive therapy.

Autoimmune Disorders Respond Well  A recent pilot study found that LDN improves mood, cognition, and pain scores in patients with progressive multiple sclerosis. And researchers from Pennsylvania State University College of Medicine demonstrated that 67 percent of patients with Crohn’s disease who were treated with 4.5 mg of LDN for 12 weeks went into remission. The buzz from patients is even better than the studies. Vicki Finlayson had suffered with debilitating multiple sclerosis. After 10 years of unbearable pain, horrible fatigue, growing depression, and dependence on Vicodin and morphine to control her pain, Vicki learned about LDN. Once she started taking it –  after her doctor initially refused to prescribe it and she had to wean herself off opioid painkillers – she got her life back. She’s been back at work a year and a half now, she’s off all other drugs, and she’s feeling great.

Recommendations  In addition to the conditions discussed above, LDN is an excellent therapy for general health enhancement and disease prevention. The only contraindication is narcotic drugs. LDN blocks their effects and could cause withdrawal symptoms, so it should be started only after those drugs are completely out of your system. LDN is safe and well tolerated. Some people report vivid dreams at first, but in my clinical experience, sleep disturbances are rare. To avoid this, you may want to start with a [low] dose… and build up slowly over two months. To learn more about LDN, visit lowdosenaltrexone.org or simply surf the Internet. This will give you a feel for patient enthusiasm for LDN. ~ Julian Whitaker, MD.”

                                        Purchasing Naltrexone

LDN from the NHS
Hundreds of GP’s are prescribing LDN on the NHS in Britain, but they will only prescribe if you are a patient and live within their catchment area, so go ahead and provide this LDN Packet to your own GP first. If they refuse to prescribe, contact the practice manager of other GP surgeries in your area and ask if any of their doctors will prescribe LDN for you if you become a patient. Many people have done this with success.

Crystal Nason Ferguson keeps a list of legally prescribing doctors from all over the world. Please email her at: angelindisguiseldn@yahoo.com. Crystal’s website: http://crystalangel6267.webs.com/mystory.htm

Dr. Tom Gilhooly of Scotland prescribes LDN for many of his patients:  http://www.ldnresearchtrust.org/ldn-information/58-dr-tom-gilhooly-mbchb-mrcgp.asp

Websites that sell LDN & Naltrexone

This information is provided for an International audience. You take full responsibility for your actions under the laws of the country in which you live.

http://www.webspawner.com/users/howtoobtainldn/index.html http://www.ldnaware.org/ldn-info/101-pharmacies-and-chemists-usa.asp

International Websites

A pharmacy may accept PayPal, but it can only be used for non-Rx items for legal reasons. It can be safer to use a Prepaid Visa from walmart.com

Belmar Pharmacy 90 pills of 3 mg @ $46.00 ship= $0 1-303-763-5533 http://belmarpharmacy.com/

All Day Chemist
10 pills of Revia @ $16.80+50 pills of 50 mg @ $84.00+$25.00 ship = $2.18 per pill  https://www.alldaychemist.com/search.php?search_query=Naltima

Mexican Pharmacy (script needed only if you live in Mexico) 30 pills of 50 mg @ $148.00+$12.00 ship = $5.33 per pill http://NaltrexoneRx.com

Euro Drugs 30 pills of 50 mg @ $133.00+$35.00 ship = $5.60 per pill EuroDrugstore.EU

Anti-Aging, U.K. 30 pills of 4.5 mg @ $49.99+? ship = $1.67 per pill before shipping http://www.antiaging-systems.com/113-naltrexone

River Pharmacy, Canada Complaints have been made about the consistency of their Naltima pills. Buy at your own risk!  IF you do end up using these pills, it is recommended to make a 3-pill LDN solution to help even out the consistency of each dose. https://www.riverpharmacy.ca/drug/revia

United Pharmacies, India. Complaints have been made about the strength of their Nodict pills. There are also recent reports of fraudulent use of credit cards used there. It is recommended that you use an International cash card in the exact amount required to make purchases from this site. Trust the quality and use your personal credit/debit card at your own risk!   IF you do end up using these pills, it is recommended to make a 3-pill LDN solution to help even out the consistency of each dose. https://secure.unitedpharmacies.com/customer/search.php?substring=Nodict

Compounded price for 1 month supply is usually around $30. The following pharmacies are familiar with compounding Low Dose Naltrexone (specify a fast-release form!)

The Compounding Apothecary  Edmonds, WA (877) 522-4466  (prescription required)

Grandpa’s Compounding Pharmacy  Placerville, CA (530) 622-2323 (prescription required)

Clinic Pharmacy  Oshawa, Ontario, Canada (905) 576-9090 (prescription required)

Pacific Compounds  Forest Grove, OR (877) 357-1771 (prescription required)

The Compounder  Pharmacy, Aurora, IL (800) 679-4667 (prescription required)

Apothecary Options  Chico, CA (866) 586-4633 (prescription required)

Irmat Pharmacy  New York, NY (212) 685-0500 Village Apothecary  New York, NY (212) 807-7566 (prescription required)

The Pharmacy Shoppe  Canandaigua, NY (800) 396-9970 (prescription required)

The Medicine Shoppe  Arlington, TX (prescription required)

The Prescription Center  La Crosse, WI (800) 203-9066 (prescription required)

Smith’s Pharmacy  Toronto, Ontario, Canada (800) 361-6624 (prescription required)

Canadian Apothecary  London, Ontario, Canada (519) 439-4100 (prescription required)

The Medicine Shoppe  Toronto, Ontario (416) 239-3566 (prescription required)

Dartnell’s Pharmacy  Melbourne, Australia (prescription required)

Women’s International Pharmacy  Youngtown, AZ  http://www.womensinternational.com (800) 279-5708 (prescription required)

Medaus Pharmacy  Birmingham, AL (205) 981-2352 (prescription required)

Marble City Pharmacy  Sylacauga, AL (256) 245-4446 (prescription required)

Cantrell Drugs  Little Rock, Arkansas (501) 663-6368 (prescription required)

Reed’s Compounding Pharmacy  Tucson, AZ 85716 (520) 318-4421 (prescription required)

Avondale Neighborhood Compounding Pharmacy  Avondale, AZ 85392 (623) 932-9800 (prescription required)

Apothecary Options  Chico, CA (866) 586-4633 (prescription required)

PLEASE send me contact info for any trusted pharmacy not in the list.

***************************************************************************** How to Make Oral LDN Solution with 50 mg prescription Naltrexone pill

A video showing how to do this: http://www.youtube.com/watch?v=bOekLFIvR7I&feature=related

Each 50 mg pill is mixed in 50 ml of distilled bottled water. 1 ml of the mixture = 1 mg of LDN.

1)  Use a needle-less syringe and a container with a wide opening (get a free syringe and orange prescription bottle with a pop-top from the pharmacy).

2)  To fill, draw water up to the 5 ml line on the syringe TEN times and squirt it into the container for a total of 50 ml. (If using a 10 ml syringe, draw up 10 ml FIVE times). Use a permanent marker to make a line on the outside of the container at the top of the water line and cover that with clear tape so it won’t rub off. View the liquid level by placing the container on a flat surface to make sure it is always consistent.

3)  Now fill the container to the line, throw in a pill and let it sit for an hour or so to dissolve. It is not necessary to crush the pill.

4)  Shake the mixture very well once the pill is dissolved. Thereafter, do not shake it when taking a dose. The white filler settles to the bottom of the container. Handle the container carefully to keep the filler from mixing in and do not draw up the white substance. Medications work better without the fillers. Once the liquid has been used up, discard the filler and rinse and dry before making another batch. Store it in the refrigerator in very warm weather, but this is not necessary if you plan to use it up within a few days.

5)  The blood plasma half-life of LDN is about 4 hours. Since you want the LDN out of your system by the time endorphin levels peak (generally between 2-4 a.m.), take my dose each night at 10 PM during Daylight Savings. During winter months take it at 9 p.m.

One can also use topical LDN, which can be compounded at special pharmacies.
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Titration

Dr. Jaquelyn McCandless states that one should never skip a dose of LDN for the first six months of use, as this can cause confusion in immune response. After 6 months or so, if a dose is accidentally skipped, this is not so severe, but she recommends never skipping a dose on purpose unless it is unavoidable.

                                                            Dosage

Dosage is often determined by trial and error. Most educated users start with .50 mg for 3 weeks and only experience mild side-effects. If your liver is ever seriously compromised, a lower dose may be needed. Those with Hashimoto’s and Adrenal Fatigue should start out very slowly and carefully – LDN can activate issues before addressing them, and going up too quickly can cause unneeded stress.

ONE FULL YEAR is the recommended period to trial LDN to know for certain whether it will work for a health issue
. LDN can greatly help with adrenal fatigue, but it happens in a roundabout, indirect manner over time. It can be a year or more before one might notice changes in adrenal function.

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Side-Effects

Lasting clinical side-effects have not been reported for Low Dose Naltrexone, and very few lasting, adverse reactions have ever been reported. Many LDN users report that even when they do experience mild sleep issues, they do not wake up exhausted, or struggle with fatigue the following day.

Herxheimer Reaction http://www.lauricidin.com/herxheimer_reaction.asp
Rapid killing-off of large amounts of fungus, bacteria and/or viruses in the body can make one feel very ill, and may occur when LDN is first started if the initial dose is too high. This is one good reason it is recommended to raise dosage slowly over a period of weeks, and use whatever other supplements or medications are needed to combat infection, fungus or viruses.

More LDN Facts
LDN is mainly excreted in the urine with 60% of an orally administered dose recovered over a 48-hour period and only 23% excreted through the bowel. LDN has a half-life of about 10 hours and is approximately 20% bound to protein.

LDN induces a sharp increase in pituitary and adrenal production of beta-endorphin and metenkephalin in the pre-dawn hours between 2 am and 4 am, when 90% of the manufacturing of those hormones occurs. Most studies have shown that Low-dose Naltrexone induces a two- to three-fold increase in the production of metenkephalin overnight. LDN only stays in the system 4 to 5 hours, so if it is taken it too early in the evening, the peak endorphin production time is missed. Taken at other times of day, the endorphin boost may not be enough to halt disease progression if disease is chronic and progressive. LDN not only increases endorphin production; over time it also increases the number of important immune cell receptors that use endorphins.

OFF-LABEL USE. While it is illegal for a pharmaceutical company to market or promote a drug for a use other than that approved by the FDA, it is NOT illegal for a physician to prescribe an FDA-approved drug for a non-FDA-approved use. This is called an “off-label” prescription, and physicians do it every day. Neurontin was approved by the FDA in 1993 for the treatment of epilepsy; yet it is routinely prescribed off-label for the treatment of MS. All physicians understand that the responsible off-label use of an FDA-approved medication such as Naltrexone is perfectly ethical and legal.

A Talk by Dr. Tom Gilhooly (edited slightly)

“The 2nd European LDN conference in Glasgow this year saw the first presentation of a remarkable study into LDN for the treatment of fibromyalgia by Dr Jarred Younger of Stanford University. This is the sort of top quality research that we have been crying out for, and perhaps even more remarkable than the results of the study was Dr Younger’s clarity on how LDN works. The vacuum that has existed in LDN research has been filled by lots of myths and legends, such as timing of administration and dosage of the drug. Dr Younger explained that LDN is a “racemic mix” of mirror image right- and left-handed molecules. This is common in chemistry, and most drugs consist of such a natural mix. It is usual for only one of the sides to be biologically active, but in the case of LDN, both sides are active. The right handed molecule blocks the opiate receptors, which confer the action the drug is licensed for i.e., blocking the action of heroin and other illicit opiates.  The more interesting part regards the left-handed molecule, which acts on the Toll-like 4 receptors on the surface of immune cells and acts as an immune modulator. Dr Younger studied the effect on microglial cells, a type of immune cell important to the neurological system, which becomes active when the immune system is activated. These cells are important in fibromyalgia, but also in MS, Parkinson’s, and other neurological conditions. The left-handed Naltrexone binds to these receptors and reduces the inflammatory chemicals that are pouring out of these cells. This idea makes great sense and fits very well with our findings in the clinic. If this is the mode of action, it fits with the hypothesis of Dr Agrawal and others… This is a big discovery… This would suggest that the opiate-blocking effect of LDN is actually the limiting factor on dose and we should aim to get the highest dose possible that the patient can tolerate, to produce the greatest effect on the immune system. It also puts paid to the idea that LDN is an ‘immune booster’ that should not be used with other immune modulators: In fact, it is likely that LDN will be synergistic with these drugs. As if this were not enough … along comes the much-anticipated double-blind study on Crohn’s Disease by Prof Jill Smith and Ian Zagon from Penn State. This shows a remarkable 83% improvement in the LDN group, with almost half going into remission… In Crohn’s disease and other inflammatory bowel diseases including Celiac, there is an increase in Toll Like 4 Receptor numbers on the bowel mucosa. This could explain the rapid and dramatic response to LDN of many patients with these conditions.”

Cautionary Warnings! http://www.webspawner.com/users/avoidthesedrugsonldn/index.html

OPIATES. Because LDN blocks opioid receptors throughout the body for three to four hours, users cannot take a long-term narcotic like Hydrocodone, Morphine, Percocet, or codeine-containing medication. Patients who have become dependent on daily use of narcotic-containing pain medication may require 10 days to 2 weeks to wean off of it completely before starting LDN, but it is well worth the effort!  Substitute one of these non-narcotic painkillers approved for use with LDN when weaning off narcotics:  Moxxor, Aspirin, Tylenol, Advil, Motrin, Aleve, Naprosyn, Ansaid, Dolobid, Orudis, Voltaren, Feldene, or Mobic. The food supplement DL-Phenylalanine (DLPA) is said to enhance the effectiveness of LDN and can be taken twice a day on an empty stomach in doses of 500 mg.

MS DRUGS. Some MS drugs are not indicated for use with LDN. If there is any doubt, please submit to your doctor a full list of the drugs you are presently taking so that their compatibility may be assessed. Dr. M.R. Lawrence talks about LDN for MS: http://www.webspawner.com/users/sideeffectsofldn/index.html, http://tinyurl.com/treating-ms-relapses

STEROIDS. In the past it was believed one should not take them with LDN, but currently many use oral steroids like Prednisone (up to 10) and Hydrocortisone (up to 40) while taking LDN.

PLAQUENIL (Hydroxychloroquine). LDN and Plaquenil can be taken together. The LDN Research Trust group on Facebook has members who take both successfully.

CHEMOTHERAPY. There is no known problem combining LDN with chemotherapy, and in theory (based on work done with animals), LDN could enable the chemo to work more effectively. This is because LDN raises OGF levels that act to slow down cell division, enabling the chemo to achieve a greater effect than if taken alone. However, if any opiate pain killers are being taken with the chemotherapy, LDN would neutralize the effect of the painkillers for several hours.

FILLERS   http://www.lowdosenaltrexone.org/gazorpa/LDNFillers.html


Calcium Carbonate. Some pharmacies and manufacturers use a substance called Calcium Carbonate as filler when compounding or making pills, which makes the medication time-release or slow-release in the body. LDN stimulates the body to create high endorphins at a specific time. It is this endorphin boost that triggers the immune system to modulate. Basically one wants as many endorphins as possible to jump-start the immune system. If the Naltrexone pill has CC as the filler, the drug will be slow-release and the body will never achieve that high level of endorphins. This basically shoots down any chance of getting the maximum potential for the immune system. This is an even bigger concern for cancer patients who need immediate results from LDN.

Some users who switched brands of LDN had a return of their symptoms. The brands they switched to had Calcium Carbonate as filler. Dr. Bihari confirmed this in an interview, saying that anyone on LDN, particularly a cancer patient, should avoid Calcium Carbonate at all times. Check the ingredients of every supplement and medication for Calcium Carbonate, especially Alpha Lopioc Acid and B-Complex vitamin pills.  Common fillers that seem to have no adverse effect on LDN uptake are Lactose, Acidophilus and Avicel (which is a fast-releaser). Dr. Bihari has been quoted as saying Lactose is his preference. Ask the pharmacist and avoid Calcium Carbonate to get the most out of each LDN dose.

LDN has the top-rated ability to raise endorphin counts. Dr. Bihari said that about 65% of his patients experienced a complete stop of disease progression. Of those, 30% went into full remission. If success is reliant on endorphin production; then perhaps we should be focusing on doing other things to stimulate that. Some natural ways to do this are aerobic exercise and acupuncture. Chocolate has a substance called Phenylalanine, which slows the breakdown of endorphins in the body.

Books

Google LDN by Joseph Wouk (e-book no longer free) http://video.google.com/videoplay?docid=4440379733824898139

201 Reasons for LDN by the LDN Research Trust for International LDN Awareness Week 18-24 October 2010. (free e-book attached with this email). Download http://www.ldnresearchtrustfiles.co.uk/docs/eBook.pdf

The Faces of Low Dose Naltrexone created for the First International Low Dose Naltrexone Awareness Week. (free e-book attached with this email) Download http://ebookbrowse.com/ebook-sept-14-09-the-faces-of-low-dose-naltrexone-pdf-d85722067

Those Who Suffer Much Know Much – Low Dose Naltrexone (LDN) Why Weren’t You Told? 51 case studies compiled by Cris Kerr of Case Health, fifth revised. (free e-book attached with this email) Download http://www.keephopealive.org/naltrexonecasereports.pdf

The Promise of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders by Elaine Moore, McFarland Publishing. Up the Creek with a Paddle: Beat MS and All Autoimmune Disorders with LDN, by Mary Bradley.

Websites, Groups & LINKS

Facebook

http://www.facebook.com/groups/LDNRT/?ref=ts&fref=ts   LDN Research Trust Group.

Other Links

http://www.rsds.org/2/library/article_archive/pop/Younger_LowDoseNaltrexone.pdf  Fibromyalgia Study.

http://www.googleldn.com/  Joseph Wouk’s website.

www.curetogether.com  a consumer driven Health 2.0 company that brings patients with hundreds of conditions together in overlapping data communities, to share and learn from each other privately.

www.lowdosenaltrexone.org  Dr. Bihari’s 20 years of clinical experience with LDN for MS, cancer, HIV

http://www.inspire.com/groups/…/success-with-ldn-treatment  Scleroderma Foundation LDN discussions.

http://www.ldners.org/resources.htm  UK LDN Research Petition Drive and Interview.

http://www.lowdosenaltrexone.org/gazorpa/PatientGuide.html  How To Talk to Your Doctor about LDN.

http://www.youtube.com/watch?v=mDIuzw6LyiI  http://www.youtube.com/watch?v=1fzqY42rvTY  LDN Q & A Video Parts 1 & 2

http://www.ldndatabase.com/  LDN World Database. Not just anecdotes — this is Patient Based Evidence!  Post your results!

http://www.lowdosenaltrexone.org/ldn_latest_news.htm  Project LDN: Funding Clinical Trials – and organizer of the USA LDN Conferences.

http://www.patientslikeme.com/  Resource for tracking diseases and many patients using LDN.

http://www.thisisms.com/forum/low-dose-naltrexone-f10/  LDN & MS, with a Forum.

crystalangel6267.webs.com/  Crystal’s LDN Website.

http://www.ldnresearchtrust.org/  Fund raising for a clinical trial of LDN against MS.

http://www.ldn.org.pl/  Polish Language LDN Site.

groups.yahoo.com/group/lowdosenaltrexone/  Yahoo discussion group.

groups.yahoo.com/group/Autism_LDN  Autism LDN Yahoo Group – information from Dr. Jaquelyn McCandless. Check the Files section.

http://www.ldn-for-fibro.com/  Discussion group.

http://www.ldn4cancer.com  Dee’s story, including published papers on treating cancer w/ LDN.

ldn.proboards.com/index.cgi   Dr. McCandless Autism discussion board

http://www.ldnafricaaids.org/  Mali HIV + AIDS LDN Initiative Dr. McCandless.

http://www.lowdosenaltrexone.org/  LDN Org.

hwww.ldnscience.org/users-stories  User’s Stories.

http://www.ldnresearchtrust.org/ LDN Research Trust.

http://articles.mercola.com/sites/articles/archive/2011/09/19/one-of-the-rare-drugs-that-actually-helps-your-body-to-heal-itself.aspx  Doctor Mercola supports LDN use.

http://thecompounder.blogspot.com/2012/06/relieve-itching-with-naltrexone-cream.html  Article on topical LDN cream.

Pets & LDN

http://www.ldndatabase.com/pets.html  Database for pets on LDN

www.skipspharmacy.com  Dr. Skip Lenz knows quite a bit about LDN for pets.

http://health.groups.yahoo.com/group/LDN_4_Pets/   a Yahoo group.

http://www.lowdosenaltrexone.org/ldn_trials.htm#Animal Clinical trials.
            A Working List of Conditions and Diseases for which LDN is used

Google “LDN” or “LDN+any condition” for more information. For videos, go to Youtube and search for “LDN” or “Low Dose Naltrexone”.

ADHD/ADD
Acute Disseminated Encephalomyelitis
Acute Hemorrhagic Leukoencephalitis
Addison’s Disease
Adrenal Fatigue
Agammaglobulinemia
Allergies
Alopecia areata
Alzheimer’s
Amyotrophic Lateral Sclerosis (ALS)
Ankylosing Spondylitis
Anti-GBM/TBM Nephritis
Antiphospholipid syndrome
Antisynthetase syndrome
Aphasia/Dysphasia/Dysnomia
Asperger’s
Asthma (autoimmune mast cell and other types)
Atopic allergy
Atopic dermatitis
Autism Spectrum Disorders
Autoimmune aplastic anemia
Autoimmune cardiomyopathy
Autoimmune enteropathy
Autoimmune Hemolytic Anemia
Autoimmune Hepatitis
Autoimmune inner ear disease
Autoimmune lymphoproliferative syndrome
Autoimmune pancreatitis
Autoimmune peripheral neuropathy
Autoimmune polyendocrine syndrome
Autoimmune Polyendocrinopathycandidiasis-ectodermal Dystrophy (APECED)
Autoimmune progesterone dermatitis
Autoimmune thrombocytopenic purpura
Autoimmune urticaria
Autoimmune uveitis
Balo disease/Balo concentric sclerosis
Becker’s Disease
Behcet’s Syndrome/Disease
Berger’s disease
Bickerstaff’s encephalitis
Bipolar Disorder
Bladder Cancer
Blau Syndrome
Brain Fog/ Memory issues
Breast Cancer
Bullous pemphigoid
Cancer: http://www.lowdosenaltrexone.org/ldn_and_cancer.htm
Carcinoid
Castleman’s disease
Celiac disease
Chronic Fatigue Syndrome (CFS)
Chronic inflammatory demyelinating polyneuropathy
Chronic Obstructive Pulmonary Disease (COPD)
Chronic Recurrent Multifocal Osteomyelitis
Churg-Strauss syndrome
Cicatricial pemphigoid
Cogan syndrome
Cold agglutinin disease
Colon & Rectal Cancer
Common Cold/Flu/Pneumonia
Complement component 2 deficiency
Cranial arteritis
CREST Syndrome
Crohn’s Disease http://www.posterwall.com/blog_attachment.php?attachmentid=2477&d=1300033072, http://jeffreydach.com/2009/01/12/crohns-recovery-with-low-dose-naltrexone-ldn-by-jeffrey-dach-md.aspx?ref=rss
Cushing’s Syndrome
Cutaneous leukocytoclastic angiitis
Depressed Immune Function
Depression/Social Withdrawal http://davidnixon.posterous.com/the-beneficial-by-products-of-low-dose-naltre
Dermatomyositis
Diabetes
Emphysema (COPD)
Endometriosis
Endorphin/Dopamine Deficiency Syndrome https://www.facebook.com/note.php?note_id=423708181450
Epstein-Barr Virus (EBV/CEBV)
Esophageal Spasm
Fibromyalgia http://www.webspawner.com/users/ldnforfms/
Food Sensitivities
Gingivitis
Glioblastoma
Hashimoto’s Thyroiditis
Heat Stroke http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1997.tb51745.x/abstract, http://www.jstage.jst.go.jp/article/jphs/97/4/97_519/_article
Herpes/HSV
HIV/AIDS http://www.academicjournals.org/jahr/PDF/Pdf2011/October/Traore%20et%20al%20%281%29.pdf
Hypoglycemia/Severe Reactive (postprandial) Hypoglycemia
Hypothermia http://www.jstage.jst.go.jp/article/jphs/97/4/97_519/_article
Infertility
Insulin Resistance
Interstitial Cystitis (IC)
Irritable Bowel Syndrome (IBS)
Liver Cancer
Lung Cancer (Non-Small Cell)
Lyme Disease
Lymphocytic Leukemia (chronic)
Lymphoma (Hodgkin’s and Non-Hodgkin’s)
Malignant Melanoma
Migraine
Multiple Autoimmune Syndrome (MAS)
Multiple Chemical Sensitivity (MCS)
Multiple Myeloma
Multiple Sclerosis (MS)
Murine Inflammatory Bowel Disease
Myalgic Encephalomyelitis (ME, post viral illness)
Myasthenia Gravis
Neuroblastoma
Neuropathy
Obsessive Compulsive Disorder (OCD)
Ocular Rosacea
Ovarian Cancer http://www.ncbi.nlm.nih.gov/pubmed/21531450, http://www.sciencedirect.com/science/article/pii/S0090825811008663
Pancreatic Cancer
Parkinson’s Disease
Pemphigoid
Polycystic Ovarian Disease (PCOD) or Syndrome (PCOS)
Polymyalgia Rheumatica (PMR)
Post-Exertional Neuroimmune Exhaustion (PENE)
Post-Herpetic Neuralgia
Premenstrual Syndrome (PMS)
Primary Lateral Sclerosis (PLS)
Prostate Cancer (untreated)
Psoriasis
Reflex Sympathetic Dystrophy (RSD)
Renal Cell Carcinoma
Restless Leg Syndrome (RLS)
Reynaud’s Syndrome
Rheumatioid Arthritis (RA)
Rosacea
Sacoidosis
Scleroderma (Stiff Person Syndrome (SPS) &Diffuse)
Seizures
Self-injurious behaviors
Sensitivity to heat and cold http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1997.tb51745.x/abstract, http://www.jstage.jst.go.jp/article/jphs/97/4/97_519/_article
Shingles (chronic)
Sjogren’s Syndrome
Sleep Disorders
Systemic Lupus Erythematosis (SLE)
Throat Cancer
Torticollis
Transverse Myelitis
Ulcerative Colitis
Uterine Cancer
Wegener’s Granulomatosis
Wounds http://ebm.rsmjournals.com/content/early/2011/09/13/ebm.2011.011163.short

Other Cancer Links
http://www.ncbi.nlm.nih.gov/pubmed/21584896
http://www.lowdosenaltrexone.org/ldn_and_cancer.htm
http://ldn.proboards.com/index.cgi?board=personal&action=display&thread=816
http://www.mbschachter.com/protocol_for_low.htm
http://www.webspawner.com/users/ldnforcancer/index.html
http://jeffreydach.com/2007/08/01/low-dose-nalotrexone-ldn-by-jeffrey-dach-md.aspx 

 

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